Microwave-assisted domino access to C2-chain functionalized furans from tertiary propargyl vinyl ethers
Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed into trisubstituted C2-chain functionalized furans. The metal-free domino transformation involves a microwave-assisted tandem [3,3]-propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed in a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols). © 2011 American Chemical Society.
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Format: | artículo biblioteca |
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American Chemical Society
2011-07-22
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Online Access: | http://hdl.handle.net/10261/132565 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 |
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