Method for modifying derivatives of amino acids and peptides, compounds produced, and use
[EN] The invention relates to a novel method for modifying hydroxylated cyclic amino acids, especially 4-hydroxyproline, which is a commercial, relatively cheap, natural amino acid, in order to provide other amino acids of high optical purity. The initial step of the process is a free-radical excision, and the excision product converts itself into non-proteinogenic amino acids by means of reactions such as reduction, reductive amination, and Horner-Wadsworth-Emmons reactions. The method is characterised in that it is applicable to the selective modification of peptides. The invention also relates to the products of said method, such as amino acids that are N-alkylated and/or have side chains with groups of amino, hydroxyl, alkenyl etc., and to the peptidic derivatives thereof of interest as pharmaceuticals, catalysts, molecular imaging probes etc.
| Main Authors: | , |
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| Format: | solicitud de patente biblioteca |
| Language: | Spanish / Castilian |
| Published: |
2014-08-21
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| Online Access: | http://hdl.handle.net/10261/125023 |
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