The role of pulmonary intravascular macrophages in the pathogenesis of African horse sickness

African horse sickness (AHS) is a disease of equids, characterized by severe pulmonary oedema and caused by an orbivirus. To determine the role of pulmonary intravascular macrophages (PIMs) in the development of pulmonary microvascular changes in this disease, five horses were given an intravenous inoculation of 106 TCID50 of serotype 4 of AHS virus. Viral replication was detected in endothelial cells, PIMs, interstitial macrophages and fibroblasts. Alveolar and interstitial oedema, and changes in pulmonary microvasculature, consisting mainly of the sequestration of neutrophils and the formation of platelet aggregates and fibrous microthrombi, were related to endothelial changes and to a high degree of PIM activation. This suggested that the PIMs, once activated, contributed to these vascular changes by releasing chemical inflammatory mediators.

Bibliographic Details

Main Authors:	Carrasco, L., Sánchez, C., Gómez-Villamandos, J. C., Laviada, M. D., Bautista, M. J., Martínez-Torrecuadrada, J., Sánchez-Vizcaíno, J. M., Sierra, M. A.
Format:	journal article biblioteca
Language:	eng
Published:	1999
Online Access:	http://hdl.handle.net/20.500.12792/5763
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