Reproduction and brain. I morphofunctional basis of brain control Advances and therapeutical implications
For many years, the control of reproduction has been considered a brin function, being the hypothalamus the CNS region directly involved. The main neurons described in recent years related to reproduction are the secretory neurons of GnRH, GnIH and Kisspeptine (gonadotropin-releasing hormone; the gonadotropin-inhibitory hormone and by the peptide Kisspeptine-GnRH regulatory neurons), but it is still unknown whether other pituitary gonadotropin regulatory peptides exist as well as other neurons (or peptides) that produce regulatory factors for these neurons. It is known that these neurons are formed by subsets that can secrete other substances and/or be regulated in different ways. The great variability of the synaptic connections and the secretion of neuropeptides seem to indicate that it is necessary to know the specific "functional modality" (or specific picture of a situation in an individual of a species) rather than the cells involved in a process. The complex interrelationship of the morphofunctional subtypes of secretory and nonsecreting neurons of the different nuclei or areas of the hypothalamus related to reproduction raises doubts about the therapeutic performance. Possible pharmacological and non-pharmacological treatments, specifically stimulating some neuronal types, may have important side effects by disregarding collateral connections to other systems or by ignoring the existence of neurons of a subtype in other functional "axes" of the hypothalamus.
| Main Authors: | , , |
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| Format: | review biblioteca |
| Language: | eng |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.12792/4491 |
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