IL-10 A multifunctional cytokine in viral infections
The anti-inflammatory master regulator IL-10 is critical to protect the host from tissue damage during acute phases of immune responses. This regulatory mechanism, central to T cell homeostasis, can be hijacked by viruses to evade immunity. IL-10 can be produced by virtually all immune cells, and it can also modulate the function of these cells. Understanding the effects of this multifunctional cytokine is therefore a complex task. In the present review we discuss the factors driving IL-10 production and the cellular sources of the cytokine during antiviral immune responses.We particularly focus on the IL-10 regulatory mechanisms that impact antiviral immune responses and how viruses can use this central regulatory pathway to evade immunity and establish chronic/latent infections. Copyright © 2017 José M. Rojas et al.
| Main Authors: | , , , |
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| Format: | review biblioteca |
| Language: | eng |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.12792/3865 |
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