Studies on aromatic compounds Inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids
With the objective to understand structural features responsible for the biological activity, novel nonelectrophilic biphenyl derivatives and peptide-biphenyl hybrids have been synthesized and evaluated as calpain I inhibitors. The preliminary results indicate that the presence of additional aromatic rings (besides the biphenyl system) makes these compounds potent calpain inhibitors with IC50 values in the nanomolar range. © 2004 Elsevier Ltd. All rights reserved.
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | journal article biblioteca |
| Language: | eng |
| Published: |
2004
|
| Online Access: | http://hdl.handle.net/20.500.12792/2934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|