Dysregulation in host sphingolipid metabolism caused by West Nile virus infection as a potential disease progression biomarker and new therapeutic target

West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected Culex sp mosquitoes and it is widely distributed across Europe. Severe forms of West Nile disease (WND) can cause meningitis, encephalitis or even death. In 2020, WNV caused an outbreak in southwest Spain that ended up with 70 human infections and 7 deaths. There are no vaccines or specific drugs to prevent and treat the symptoms of WND in humans, so the search for novel targets for therapeutic interventions is mandatory. Lipid metabolism is gaining interest as a potential target to combat flavivirus using a host-targeted approach.

Bibliographic Details

Main Authors:	Mingo-Casas, Patricia, Sanchez-Céspedes, Javier, Blázquez, Ana B., Casas, Josefina, Balsera-Manzanero, María, Herrero, Laura, Vázquez, Ana, Pachón, Jerónimo, Aguilar-Guisado, Manuela
Other Authors:	European Commission
Format:	comunicación de congreso biblioteca
Language:	English
Published:	CSIC - Centro de Ciencias Humanas y Sociales (CCHS) 2023-11-20
Online Access:	http://hdl.handle.net/10261/351333
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