Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain

A significant frequency of amino acid substitutions, that affect important antigenic sites on capsid protein VP1, has been found among viral preparations used for the production and for challenge, in protection assays, of foot-and-mouth disease (FMD) vaccines. The amino acid substitutions present in one of the viruses studied abolished its reactivity with two neutralizing monoclonal antibodies that recognized different epitopes on VP1. Thus, the results obtained illustrate the high potential for antigenic variation introduced by the multiple cycles of growth usually undergone by the strains used for the production and challenge of FMD vaccines. © 1992.

Bibliographic Details

Main Authors:	González, M., Mateu, M. G., Martínez, M. A., Carrillo García, Mª Cristina, Sobrino, F.
Format:	journal article biblioteca
Language:	English
Published:	Elsevier 1992
Subjects:	FMD vaccines, Production and challenge viruses, VP1 RNA sequences comparison,
Online Access:	http://hdl.handle.net/20.500.12792/5148 http://hdl.handle.net/10261/294906
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