Four genes located on a SSC2 meat quality QTL region are associated with different meat quality traits in Landrace × Chinese-European crossbred population
Several quantitative trait loci (QTL) for different meat quality traits have been localized on the q arm of porcine chromosome 2 at position 55-78 cM. Association analyses were performed in a commercial Landrace × Chinese-European (LCE) crossbred population (n = 446) slaughtered at approximately 127 kg and an average age of 198 days with records for performance (growth, fat and meat accretion) and meat quality [intramuscular fat (IMF), Minolta L*, Minolta a*, Minolta b* and pH at 45 m]. Polymorphisms within positional candidate genes cloned from homologous regions on human chromosome 19, ubiquitin-like 5 (UBL5- AM950288g.566G>A), resistin (RETN- AM157180g.1473A>G causing substitution p.Ala36Thr), insulin receptor (INSR- AM950289g.589T>C) and complement factor D (adipsin) (CFD- AM950287g. 306C>T) were located at positions 62.1, 64.0, 68.0 and 70.7 cM respectively on the current USDA USMARC map of porcine chromosome 2 and had the following allele frequencies in the LCE UBL5 566G - 0.57; RETN 1473G - 0.84; INSR 589C - 0.70; and CFD 306C - 0.73. The effects of alleles within the candidate genes on the recorded traits were estimated using an animal model. Significant effects (P < 0.05) were found for pH 45 in m. semimembranosus (m. sm.) (UBL5), IMF (RETN) and Minolta L* (RETN, CFD). Differences between phenotypic means of homozygotes at UBL5, RETN and either RETN or CFD explained 0.34 SD for pH 45 in m. sm.;0.47 SD for IMF and 0.68 SD for Minolta L* respectively. Suggestive effects (P < 0.10) on IMF (UBL5, CFD), Minolta a* (INSR, CFD) and Minolta b* (INSR) were also observed. Our results support the localization of further QTL for meat quality traits in this region and suggest that there are several genes affecting different meat quality traits. © 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
| Main Authors: | , , , , , , , |
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| Format: | journal article biblioteca |
| Language: | English |
| Published: |
Wiley
2012
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| Subjects: | Association study, Complement factor D (adipsin), Insulin receptor, Meat quality, Pig, Porcine chromosome 2, Resistin, Ubiquitin-like 5, |
| Online Access: | http://hdl.handle.net/20.500.12792/5843 http://hdl.handle.net/10261/293525 |
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