Characterization of a novel activation antigen on porcine lymphocytes recognized by monoclonal antibody 5A6/8

In this report, we describe the characterization of a novel activation antigen on porcine lymphocytes recognized by mAb 5A6/8. This antigen was detected on B and T cells 24 h after treatment with various stimuli. It was also found on alveolar macrophages, and at low levels on untreated monocytes. MAb 5A6/8 precipitated two bands of 45 and 50 kDa under non-reducing conditions, and of 22 and 28 kDa under reducing conditions. The cellular distribution, expression kinetics and/or molecular size of the 5A6/8 antigen differ from those of other known lymphocyte activation antigens. MAb 5A6/8 was able to inhibit lymphocyte proliferative responses driven by different stimuli, suggesting a role for this molecule in the events that lead to lymphocyte activation. © INRA, EDP Sciences, 2004.

Bibliographic Details

Main Authors:	Doménech, N., Bullido, R., Álvarez, B., Campos, E., Rodríguez-Carreño, M. P., Gómez Del Moral, M., Alonso, F., Ezquerra Martínez, Ángel, Domínguez, J.
Format:	artículo biblioteca
Language:	English
Published:	BioMed Central 2004
Subjects:	Activation antigen, Lymphocyte, Monoclonal antibody, Monocyte, Pig,
Online Access:	http://hdl.handle.net/20.500.12792/1110 http://hdl.handle.net/10261/292899
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