Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4

We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed. ©2006 American Society of Animal Science. All rights reserved.

Bibliographic Details

Main Authors:	Mercadé, A., Pérez-Enciso, M., Varona, L., Alves, E., Noguera, J. L., Sánchez, A., Folch, J. M.
Format:	artículo biblioteca
Language:	English
Published:	Oxford University Press 2006
Subjects:	FABP4, FAT1, Fatness, Pig, QTL,
Online Access:	http://hdl.handle.net/20.500.12792/5294 http://hdl.handle.net/10261/291875
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