Acute phase response in porcine reproductive and respiratory syndrome virus infection

This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Hp and Pig-MAP serum levels were increased at 10. dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1β was observed at 7. dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-α, and might be related with an increased expression of IL-10. The low expression of TNF-α might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection. © 2009 Elsevier Ltd.

Bibliographic Details

Main Authors:	Gómez-Laguna, J., Salguero, F. J., Pallarés, F. J., Fernández de Marco, M., Barranco, I., Cerón, J. J., Martínez-Subiela, S., Van Reeth, K., Carrasco, L.
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2010
Subjects:	Porcine reproductive and respiratory syndrome, Pathogenesis, Acute phase proteins, Proinflammatory cytokines,
Online Access:	http://hdl.handle.net/20.500.12792/1798 http://hdl.handle.net/10261/291748
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