SLUG in cancer development

The SNAIL-related zinc-finger transcription factor, SLUG (SNA12), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to contribute to piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. While aberrant induction of SLUG has been documented in cancer cells, relatively little is known about the consequences of SLUG overexpression in malignancy. To investigate the potential role of SLUG overexpression in development and in cancer, we generated mice carrying a tetracycline-repressible Slug transgene. These mice were morphologically normal at birth, and developed mesenchymal tumours (leukaemia and sarcomas) in almost al cases examined. Suppression of the Slug transgene did not rescue the malignant phenotype. Furthermore, the BCR-ABL oncogene, which induces Slug expression in leukaemic cells, did not induce leukaemia in Slug-deficient mice, implicating Slug in BCR-ABL leukaemogenesis in vivo. Overall, the findings indicate that while Slug overexpression is not sufficient to cause overt morphogenetic defects in mice, they demonstrate a specific and critical role for Slug in the pathogenesis of mesenchymal tumours. © 2005 Nature Publishing Group All rights reserved.

Bibliographic Details

Main Authors:	Pérez-Mancera, P. A., González-Herrero, I., Pérez-Caro, M., Gutiérrez-Cianca, N., Flores, T., Gutiérrez Adán, Alfonso, Pintado, B., Sánchez-Martín, M., Sánchez-García, I.
Format:	artículo biblioteca
Language:	English
Published:	Springer Nature 2005
Subjects:	SLUG, Development, Cancer,
Online Access:	http://hdl.handle.net/20.500.12792/3462 http://hdl.handle.net/10261/290895
Tags:	Add Tag No Tags, Be the first to tag this record!