CD200R1 and CD200R1L expression is regulated during B cell development in swine and modulates the Ig production in response to the TLR7 ligand imiquimoid

The CD200R family comprises a group of paired receptors that can modulate the activation of immune cells. They are expressed both on myeloid cells and lymphocyte subsets. Here we report that the expression of these receptors on porcine B cells is tightly regulated, being mainly expressed on mature cells. The expression of the inhibitory receptors CD200R1 and/or its splicing variant CD200R1X2, either in combination or not with the activating receptor CD200R1L, is upregulated in sIgM+ effector/memory cells, and tends to decline thereafter as these cells progress to plasmablasts or switch the Ig isotype. sIgM+ naïve and primed cells only express, by contrast, the CD200R1X2 receptor. B-1 like cells also express CD200R1 isoforms, either alone or in combination with CD200R1L. Treatment of peripheral blood mononuclear cells with a monoclonal antibody specific for inhibitory receptors, enhances the IgM and IgG production induced by TLR7 stimulation suggesting a modulatory role of B cell functions of these receptors.

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Bibliographic Details
Main Authors: Poderoso, Teresa, Martínez De la Riva, Paloma, Álvarez, Belén, Ezquerra Martínez, Ángel, Domínguez, Javier, Revilla Calvo, Concepción
Other Authors: Agencia Estatal de Investigación (España)
Format: artículo biblioteca
Language:English
Published: Public Library of Science 2021-05-07
Subjects:Antibody repertoire development, Receptor family, Identification, Rearrangement, Subsets, Member, Roles, CD27,
Online Access:http://hdl.handle.net/10261/268310
http://dx.doi.org/10.13039/501100011033
https://api.elsevier.com/content/abstract/scopus_id/85105510677
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