Bacterial 3′UTRs: A Useful Resource in Post-transcriptional Regulation
Bacterial messenger RNAs (mRNAs) are composed of 5′ and 3′ untranslated regions (UTRs) that flank the coding sequences (CDSs). In eukaryotes, 3′UTRs play key roles in post-transcriptional regulatory mechanisms. Shortening or deregulation of these regions is associated with diseases such as cancer and metabolic disorders. Comparatively, little is known about the functions of 3′UTRs in bacteria. Over the past few years, 3′UTRs have emerged as important players in the regulation of relevant bacterial processes such as virulence, iron metabolism, and biofilm formation. This MiniReview is an update for the different 3′UTR-mediated mechanisms that regulate gene expression in bacteria. Some of these include 3′UTRs that interact with the 5′UTR of the same transcript to modulate translation, 3′UTRs that are targeted by specific ribonucleases, RNA-binding proteins and small RNAs (sRNAs), and 3′UTRs that act as reservoirs of trans-acting sRNAs, among others. In addition, recent findings regarding a differential evolution of bacterial 3′UTRs and its impact in the species-specific expression of orthologous genes are also discussed.
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| Format: | artículo de revisión biblioteca |
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Frontiers Media
2021-01-08
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| Subjects: | 3′UTR, Bacteria, Gene expression regulation, RNA-binding proteins (RBPs), ncRNAs (non-coding RNAs), Regulatory small RNAs (sRNAs), Post-transcription regulation, |
| Online Access: | http://hdl.handle.net/10261/244174 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000781 |
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