Biological Calorimetry: Old Friend, New Insights

Abian, Olga; Vega, Sonia; Velázquez-Campoy, Adrián; Ministerio de Economía y Competitividad (España)

Biological Calorimetry: Old Friend, New Insights

Calorimetry is an old experimental technique (first instrument developed in S. XVIII), but it is broadly used and still provides key information for understanding biological processes at the molecular level, particularly, cooperative phenomena in protein interactions. Here, we review and highlight some key aspects of biological calorimetry. Several biological systems will be described in which calorimetry was instrumental for modeling the behavior of the protein and obtaining further biological insight.

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Bibliographic Details
Main Authors:	Abian, Olga, Vega, Sonia, Velázquez-Campoy, Adrián
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Language:	English
Published:	Molecular Diversity Preservation International 2023-03-01
Subjects:	Binding cooperativity, Biological calorimetry, Isothermal titration calorimetry, KNF or sequential model, MWC or concerted model, Protein interactions,
Online Access:	http://hdl.handle.net/10261/347607 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004587 https://api.elsevier.com/content/abstract/scopus_id/85173775748
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spelling	dig-icvv-es-10261-3476072024-05-18T20:59:29Z Biological Calorimetry: Old Friend, New Insights Abian, Olga Vega, Sonia Velázquez-Campoy, Adrián Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) European Commission Instituto de Salud Carlos III Diputación General de Aragón Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España) Abian, Olga [0000-0001-5664-1729] Velázquez-Campoy, Adrián [0000-0001-5702-4538] Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions Calorimetry is an old experimental technique (first instrument developed in S. XVIII), but it is broadly used and still provides key information for understanding biological processes at the molecular level, particularly, cooperative phenomena in protein interactions. Here, we review and highlight some key aspects of biological calorimetry. Several biological systems will be described in which calorimetry was instrumental for modeling the behavior of the protein and obtaining further biological insight. This work was supported by the Spanish Ministry of Economy and Competitiveness [BFU2016-78232-P to A.V.C.] and the Ministry of Science and Innovation MCIN/AEI/ 10.13039/501100011033/; “ERDF A way of Making Europe” [PID2021-127296OB-I00 to A.V.C.]; the Miguel Servet Program from Instituto de Salud Carlos III [CPII13/00017 to OA]; the Fondo de Investigaciones Sanitarias from Instituto de Salud Carlos III and the European Union (ERDF/ESF, “Investing in your future”) [PI18/00349 and PI21/00394 to O.A.]; the Diputación General de Aragón [Protein Targets and Bioactive Compounds Group E45_20R to A.V.C., and Digestive Pathology Group B25_20R to O.A.]; and the Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd). Peer reviewed 2024-02-20T08:58:42Z 2024-02-20T08:58:42Z 2023-03-01 artículo http://purl.org/coar/resource_type/c_6501 Biophysica 3(1): 21-34 (2023) http://hdl.handle.net/10261/347607 10.3390/biophysica3010002 2673-4125 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004587 2-s2.0-85173775748 https://api.elsevier.com/content/abstract/scopus_id/85173775748 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//BFU2016-78232-P info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127296OB-I00/ES/NUEVA ESTRATEGIA FARMACOLOGICA FRENTE A PROTEINAS DIANA DEPENDIENTES DE ZINC: INHIBIDORES ALOSTERICOS DE LAS DEACETILASAS HDAC8 Y LPXC/ info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00349/ES/“BIOPSIA LIQUIDA TERMICA (BLT): APLICACION CLINICA DEL ANALISIS DE CURVAS CALORIMETRICAS DE SUERO COMO NUEVO METODO DE DIAGNOSTICO Y SEGUIMIENTO DE PATOLOGIA DIGESTIVA TUMORAL”/ info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00394/ES/DIAGNOSTICO Y SEGUIMIENTO PERSONALIZADO DE PACIENTES CON RIESGO DE PATOLOGIA DIGESTIVA TUMORAL MEDIANTE BIOPSIA LIQUIDA TERMICA (TLB) APLICANDO HERRAMIENTAS DE INTELIGENCIA ARTIFICIAL Y NANOTECNOLOGIA/ Publisher's version https://doi.org/10.3390/biophysica3010002 Sí open application/pdf Molecular Diversity Preservation International
institution	ICVV ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-icvv-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del ICVV España
language	English
topic	Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions
spellingShingle	Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions Abian, Olga Vega, Sonia Velázquez-Campoy, Adrián Biological Calorimetry: Old Friend, New Insights
description	Calorimetry is an old experimental technique (first instrument developed in S. XVIII), but it is broadly used and still provides key information for understanding biological processes at the molecular level, particularly, cooperative phenomena in protein interactions. Here, we review and highlight some key aspects of biological calorimetry. Several biological systems will be described in which calorimetry was instrumental for modeling the behavior of the protein and obtaining further biological insight.
author2	Ministerio de Economía y Competitividad (España)
author_facet	Ministerio de Economía y Competitividad (España) Abian, Olga Vega, Sonia Velázquez-Campoy, Adrián
format	artículo
topic_facet	Binding cooperativity Biological calorimetry Isothermal titration calorimetry KNF or sequential model MWC or concerted model Protein interactions
author	Abian, Olga Vega, Sonia Velázquez-Campoy, Adrián
author_sort	Abian, Olga
title	Biological Calorimetry: Old Friend, New Insights
title_short	Biological Calorimetry: Old Friend, New Insights
title_full	Biological Calorimetry: Old Friend, New Insights
title_fullStr	Biological Calorimetry: Old Friend, New Insights
title_full_unstemmed	Biological Calorimetry: Old Friend, New Insights
title_sort	biological calorimetry: old friend, new insights
publisher	Molecular Diversity Preservation International
publishDate	2023-03-01
url	http://hdl.handle.net/10261/347607 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004587 https://api.elsevier.com/content/abstract/scopus_id/85173775748
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Biological Calorimetry: Old Friend, New Insights

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