Molecular targets of quercetin in cancer chemoprevention
Prevention of cancer through dietary intervention has received increasing interest recently, and dietary polyphenols have become important potential chemopreventive natural agents. Quercetin, among polyphenols, has been reported to interfere with the initiation, promotion and progression of cancer. It might lead to the modulation of proteins in diverse pathways and require the integration of different signals for the final chemopreventive effect. Quercetin has been demonstrated to act on multiple key elements in signal transduction pathways related to cellular proliferation, differentiation, apoptosis and inflammation; however, these molecular mechanisms of action are not completely characterized and many features remain to be elucidated. The aim of this review is to provide insights into the molecular basis of the potential chemopreventive activity of quercetin with an emphasis on its ability to control intracellular signalling cascades considered as relevant targets in a cancer-preventive approach.
| Main Authors: | , |
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| Format: | artículo biblioteca |
| Language: | English |
| Published: |
C.A.B. International
2010
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| Online Access: | http://hdl.handle.net/10261/82213 |
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