The body mass index increases the genetic risk scores' ability to predict risk of hepatic damage in European adolescents: The HELENA study

[Background]: Hepatic disorders are often complex and multifactorial, modulated by genetic and environmental determinants. During the last years, the hepatic disease has been progressively established from early stages in life. The use of genetic risk scores (GRS) to predict the genetic susceptibility to a particular phenotype among youth has gained interest in recent years. Moreover, the alanine aminotransferase (ALT) blood biomarker is often considered as hepatic screening tool, in combination with imaging techniques. The aim of the present study was to develop an ALT-specific GRS to help in the evaluation of hepatic damage risk in European adolescents.

Bibliographic Details

Main Authors:	Seral-Cortes, Miguel, Sabroso-Lasa, Sergio, González-Gross, Marcela, Quesada-González, Carlos, Stehle, Peter, Gottrand, Frederic, Marcos, Ascensión, Esperanza-Diaz, Ligia, Manios, Yannis, Androutsos, Odysseas, Widhalm, Kurt, Molnár, Dénes, Huybrechts, Inge, Muntaner, Manon, Meirhaeghe, Aline, Salazar-Tortosa, Diego, Ruiz, Jonatan R., Esteban, Luis Mariano, Labayen, Idoia, Moreno, Luis A., HELENA study group
Other Authors:	European Commission
Format:	artículo biblioteca
Language:	English
Published:	Wiley-VCH 2023
Subjects:	ALT levels, Single nucleotide polymorphism, BMI and adolescents, Hepatic disorders, GRS,
Online Access:	http://hdl.handle.net/10261/345273
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