Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts

[Background]: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress-induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown. Depression is a major public health problem which commonly starts during adolescence, thus identifying underlying mechanisms during early life is crucial in prevention. The aim of this work was to verify whether independent and interacting associations of psychosocial stress and inflammation on tryptophan breakdown already exist in children and adolescents as a vulnerable age group.

Bibliographic Details

Main Authors:	Michels, Nathalie, Clarke, Gerard, Olavarria-Ramirez, Loreto, Gómez Martínez, Sonia, Díaz, L. E., Marcos, Ascensión, Widhalm, Kurt, Carvalho, Livia A.
Other Authors:	European Commission
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2018
Online Access:	http://hdl.handle.net/10261/243583 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003130
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