A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats
[Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.
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Springer Nature
2018
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| Subjects: | Metabolites, Bioavailability, High-fat high-sucrose diet, Proanthocyanidins, Polyphenols, |
| Online Access: | http://hdl.handle.net/10261/170831 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004587 |
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dig-ictan-es-10261-1708312021-04-30T12:46:53Z A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats Molinar-Toribio, Eunice Fuguet, Elisabet Ramos-Romero, Sara Taltavull, Núria Méndez, Lucía Nogués, M. R. Medina, Isabel Pérez-Jiménez, Jara Ministerio de Ciencia e Innovación (España) Ministerio de Economía y Competitividad (España) Instituto de Salud Carlos III European Commission Secretaría Nacional de Ciencia y Tecnología (Panamá) Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols [Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes. This research was supported by the Spanish Ministry of Science and Innovation (Grants: AGL2009-12374-C03-01, -02 and -03; and AGL2013-49079-C2-1, 2 and -R, and through a doctoral fellowship to L.M.). The Panamanian Government (SENACYT/IFARHU) awarded a graduate fellowship to E.M.-T. The ISCIII is acknowledged for a “Sara Borrell” postdoctoral contract to J.P.-J. (CD09/00068). Peer Reviewed 2018-10-09T11:55:17Z 2018-10-09T11:55:17Z 2018 2018-10-09T11:55:18Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1007/s00394-016-1323-9 e-issn: 1436-6215 issn: 1436-6207 European Journal of Nutrition 57(1): 339-349 (2018) http://hdl.handle.net/10261/170831 10.1007/s00394-016-1323-9 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004587 27730364 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-49079-C2-1-R Postprint https://doi.org/10.1007/s00394-016-1323-9 Sí open Springer Nature |
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Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols |
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Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols Molinar-Toribio, Eunice Fuguet, Elisabet Ramos-Romero, Sara Taltavull, Núria Méndez, Lucía Nogués, M. R. Medina, Isabel Pérez-Jiménez, Jara A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| description |
[Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes. |
| author2 |
Ministerio de Ciencia e Innovación (España) |
| author_facet |
Ministerio de Ciencia e Innovación (España) Molinar-Toribio, Eunice Fuguet, Elisabet Ramos-Romero, Sara Taltavull, Núria Méndez, Lucía Nogués, M. R. Medina, Isabel Pérez-Jiménez, Jara |
| format |
artículo |
| topic_facet |
Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols |
| author |
Molinar-Toribio, Eunice Fuguet, Elisabet Ramos-Romero, Sara Taltavull, Núria Méndez, Lucía Nogués, M. R. Medina, Isabel Pérez-Jiménez, Jara |
| author_sort |
Molinar-Toribio, Eunice |
| title |
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| title_short |
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| title_full |
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| title_fullStr |
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| title_full_unstemmed |
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| title_sort |
high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
| publisher |
Springer Nature |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10261/170831 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004587 |
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