A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats

[Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.

Bibliographic Details

Main Authors:	Molinar-Toribio, Eunice, Fuguet, Elisabet, Ramos-Romero, Sara, Taltavull, Núria, Méndez, Lucía, Nogués, M. R., Medina, Isabel, Pérez-Jiménez, Jara
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Published:	Springer Nature 2018
Subjects:	Metabolites, Bioavailability, High-fat high-sucrose diet, Proanthocyanidins, Polyphenols,
Online Access:	http://hdl.handle.net/10261/170831 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004587
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