Model-based structure of teleost Aqp1ab1 and Aqp1ab2 and splice variants [Dataset]

(A-C) Schematic diagram of the seabream and halibut aqp1ab1 and sole aqp1ab2 genes, and the different emerging transcript variants identified in each species. The numbers represent the exons, and the initiation and stop codons in each mRNA are indicated. (D-F) Integral membrane views (cartoon renders) of the wild type and variant channels. Canonical transmembrane domains are shown in cyan, loops in magenta and the two conserved Asn-Pro-Ala (NPA) motifs in dark blue. Variant regions are shown in red. In sole Aqp1ab2_v2 (C and F), the splicing of the distal region of intron 2 causes out-of-frame readthrough of exon 3 and the spliced exon 4 resulting in a premature stop codon and the truncated protein.

Bibliographic Details

Main Authors:	Ferré, Alba, Chauvigné, François, Zapater, Cinta, Finn, Roderick N., Cerdà, Joan
Format:	dataset biblioteca
Language:	English
Published:	Plos One 2023-11-27
Subjects:	Osmoregulatory systems develop, New regulatory mechanism, Also partially escape, Maximal egg hydration, Xink "> aquaporin, Mediated oocyte hydration, Marine teleosts causes, Aqp1ab2 may represent, Two water channels, Oocyte plasma membrane, Inhibition likely occurs, Isoforms cause dominant, Canonical channel trafficking, Oocyte hydration, Marine teleosts, Cause dominant, Plasma membrane, Membrane trafficking, Canonical channels, Canonical channel, Specific aquaporin, Negative inhibition, Inhibitory isoforms, aqp1ab2 isoforms, aqp1ab2 channel, Vital water, Ultimate degradation, Type variants, Truncated proteins, Truncated protein, Truncated aqp1ab2, Thus leaving, Subsequently highest, Recent studies, Physiologically modulated, Negative enhancement, Meiosis resumption, Intact protein, Findings suggest, Exon readthrough, Endoplasmic reticulum, Early embryos, Duplicated ywhaz, Differentially control, Degradation pathway, Binding proteins, 1 cluster,
Online Access:	http://hdl.handle.net/10261/361287
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