Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review
[Background] Mitochondrial DNA (mtDNA) encodes 37 genes necessary for synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA alterations are known to cause mitochondrial disease (MitD), a clinically heterogeneous group of disorders that often present with neuropsychiatric symptoms. Understanding the nature and frequency of mtDNA alterations in health and disease could be a cornerstone in disentangling the relationship between biochemical findings and clinical symptoms of brain disorders. This systematic review aimed to summarize the mtDNA alterations in human brain tissue reported to date that have implications for further research on the pathophysiological significance of mtDNA alterations in brain functioning.
Main Authors: | , , , , , , |
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Other Authors: | |
Format: | artículo biblioteca |
Language: | English |
Published: |
Elsevier
2022-02
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Subjects: | Mitochondrial DNA, Mitochondrial diseases, Neurological diseases, Psychiatric diseases, Ageing, Postmortem, |
Online Access: | http://hdl.handle.net/10261/272320 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100004837 |
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