Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri

Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri

[Background] The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage and massive inflammation. The cellular basis distinguishing N. fowleri from other Naegleria species, which are all non-pathogenic, is not known. Yet, with the geographic range of N. fowleri advancing, potentially due to climate change, understanding how this pathogen invades and kills is both important and timely.

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Main Authors: Herman, Emily K., Greninger, Alex, van der Giezen, Mark, Ginger, Michael L., Ramírez-Macías, Inmaculada, Miller, Haylea C., Morgan, Matthew J., Tsaousis, Anastasios D., Velle, Katrina, Vargová, Romana, Záhonová, Kristína, Rodrigo Najle, Sebastian, MacIntyre, Georgina, Müller, Norbert, Wittwer, Mattias, Zysset-Burri, Denise C., Eliáš, Marek, lamovits,Claudio H., Weirauch, Matthew, Fritz-Laylin, Lillian, Marciano-Cabrol, Francine, Puzon, Geoffrey J., Walsh, Tom, Chiu, Charles, Dacks, Joel B.
Other Authors: Alberta Heritage Foundation for Medical Research
Format: artículo biblioteca
Language:English
Published: BioMed Central 2021-07-22
Subjects:Illumina, RNA-Seq, Genome sequence, Protease, Cytoskeleton, Metabolism, Lysosomal, Inter-strain diversity, Neuropathogenic,
Online Access:http://hdl.handle.net/10261/251039
http://dx.doi.org/10.13039/501100003179
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http://hdl.handle.net/10261/251039
http://dx.doi.org/10.13039/501100003179

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