A comparative genomics multitool for scientific discovery and conservation
The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
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Nature Publishing Group
2020-11-12
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Online Access: | http://hdl.handle.net/10261/236047 http://dx.doi.org/10.13039/501100002081 http://dx.doi.org/10.13039/501100004063 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100000288 http://dx.doi.org/10.13039/100000014 http://dx.doi.org/10.13039/100000011 http://dx.doi.org/10.13039/100004440 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100002341 http://dx.doi.org/10.13039/501100007051 |
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The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. |
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National Institutes of Health (US) Genereux, Diane P. Serres-Armero, Aitor Armstrong, Joel Johnson, Jeremy Marinescu, Voichita D. Murén, Eva Juan, David Bejerano, Gill Casewell, Nicholas R. Chemnick, Leona G. Damas, Joana Di Palma, Federica Diekhans, Mark Fiddes, Ian T. Garber, Manuel Gladyshev, Vadim N. Goodman, Linda Haerty, Wilfried Houck, Marlys L. Hubley, Robert Kivioja, Teemu Koepfli, Klaus-Peter Kuderna, Lukas F. K. Lander, Eric S. Meadows, Jennifer R.S. Murphy, William J. Nash, Will Noh, Hyun Ji Nweeia, Martin Pfenning, Andreas R. Pollard, Katherine S. Ray, David A. Shapiro, Beth Smit, Arian F. A. Springer, Mark S. Steiner, Cynthia C. Swofford, Ross Taipale, Jussi Teeling, Emma C. Turner-Maier, Jason Alfoldi, Jessica Birren, Bruce Ryder, Oliver A. Lewin, Harris A. Paten, Benedict Marqués-Bonet, Tomàs Lindblad-Toh, Kerstin Karlsson, Elinor K. |
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artículo |
author |
Genereux, Diane P. Serres-Armero, Aitor Armstrong, Joel Johnson, Jeremy Marinescu, Voichita D. Murén, Eva Juan, David Bejerano, Gill Casewell, Nicholas R. Chemnick, Leona G. Damas, Joana Di Palma, Federica Diekhans, Mark Fiddes, Ian T. Garber, Manuel Gladyshev, Vadim N. Goodman, Linda Haerty, Wilfried Houck, Marlys L. Hubley, Robert Kivioja, Teemu Koepfli, Klaus-Peter Kuderna, Lukas F. K. Lander, Eric S. Meadows, Jennifer R.S. Murphy, William J. Nash, Will Noh, Hyun Ji Nweeia, Martin Pfenning, Andreas R. Pollard, Katherine S. Ray, David A. Shapiro, Beth Smit, Arian F. A. Springer, Mark S. Steiner, Cynthia C. Swofford, Ross Taipale, Jussi Teeling, Emma C. Turner-Maier, Jason Alfoldi, Jessica Birren, Bruce Ryder, Oliver A. Lewin, Harris A. Paten, Benedict Marqués-Bonet, Tomàs Lindblad-Toh, Kerstin Karlsson, Elinor K. |
spellingShingle |
Genereux, Diane P. Serres-Armero, Aitor Armstrong, Joel Johnson, Jeremy Marinescu, Voichita D. Murén, Eva Juan, David Bejerano, Gill Casewell, Nicholas R. Chemnick, Leona G. Damas, Joana Di Palma, Federica Diekhans, Mark Fiddes, Ian T. Garber, Manuel Gladyshev, Vadim N. Goodman, Linda Haerty, Wilfried Houck, Marlys L. Hubley, Robert Kivioja, Teemu Koepfli, Klaus-Peter Kuderna, Lukas F. K. Lander, Eric S. Meadows, Jennifer R.S. Murphy, William J. Nash, Will Noh, Hyun Ji Nweeia, Martin Pfenning, Andreas R. Pollard, Katherine S. Ray, David A. Shapiro, Beth Smit, Arian F. A. Springer, Mark S. Steiner, Cynthia C. Swofford, Ross Taipale, Jussi Teeling, Emma C. Turner-Maier, Jason Alfoldi, Jessica Birren, Bruce Ryder, Oliver A. Lewin, Harris A. Paten, Benedict Marqués-Bonet, Tomàs Lindblad-Toh, Kerstin Karlsson, Elinor K. A comparative genomics multitool for scientific discovery and conservation |
author_sort |
Genereux, Diane P. |
title |
A comparative genomics multitool for scientific discovery and conservation |
title_short |
A comparative genomics multitool for scientific discovery and conservation |
title_full |
A comparative genomics multitool for scientific discovery and conservation |
title_fullStr |
A comparative genomics multitool for scientific discovery and conservation |
title_full_unstemmed |
A comparative genomics multitool for scientific discovery and conservation |
title_sort |
comparative genomics multitool for scientific discovery and conservation |
publisher |
Nature Publishing Group |
publishDate |
2020-11-12 |
url |
http://hdl.handle.net/10261/236047 http://dx.doi.org/10.13039/501100002081 http://dx.doi.org/10.13039/501100004063 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100000288 http://dx.doi.org/10.13039/100000014 http://dx.doi.org/10.13039/100000011 http://dx.doi.org/10.13039/100004440 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100002341 http://dx.doi.org/10.13039/501100007051 |
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dig-ibe-es-10261-2360472021-03-26T02:11:34Z A comparative genomics multitool for scientific discovery and conservation Genereux, Diane P. Serres-Armero, Aitor Armstrong, Joel Johnson, Jeremy Marinescu, Voichita D. Murén, Eva Juan, David Bejerano, Gill Casewell, Nicholas R. Chemnick, Leona G. Damas, Joana Di Palma, Federica Diekhans, Mark Fiddes, Ian T. Garber, Manuel Gladyshev, Vadim N. Goodman, Linda Haerty, Wilfried Houck, Marlys L. Hubley, Robert Kivioja, Teemu Koepfli, Klaus-Peter Kuderna, Lukas F. K. Lander, Eric S. Meadows, Jennifer R.S. Murphy, William J. Nash, Will Noh, Hyun Ji Nweeia, Martin Pfenning, Andreas R. Pollard, Katherine S. Ray, David A. Shapiro, Beth Smit, Arian F. A. Springer, Mark S. Steiner, Cynthia C. Swofford, Ross Taipale, Jussi Teeling, Emma C. Turner-Maier, Jason Alfoldi, Jessica Birren, Bruce Ryder, Oliver A. Lewin, Harris A. Paten, Benedict Marqués-Bonet, Tomàs Lindblad-Toh, Kerstin Karlsson, Elinor K. National Institutes of Health (US) Swedish Research Council Knut and Alice Wallenberg Foundation Uppsala University European Commission Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Generalitat de Catalunya Howard Hughes Medical Institute European Research Council Fundación "la Caixa" Wellcome Trust Royal Society (UK) Ministerio de Economía y Competitividad (España) Fondation Prince Albert II de Monaco Smithsonian Institution Irish Research Council Medical Research Council (UK) National Science Foundation (US) Academy of Finland The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. This project was funded by NIH NHGRI R01HG008742 (E.K.K., B.B., D.P.G., R.S., J.T.-M., J.J., H.J.N., B.P. and J. Armstrong), Swedish Research Council Distinguished Professor Award (K.L.-T., V.D.M., E.M. and J.R.S.M.), Swedish Research Council grant 2018-05973 (K.L.-T.), Knut and Alice Wallenberg Foundation (K.L.-T., V.D.M., E.M. and J.R.S.M.), Uppsala University (K.L.-T., V.D.M., E.M., J.R.S.M., J.J., J. Alfoldi and L.G.), Broad Institute Next10 (L.G.), Gladstone Institutes (K.S.P.), NIH NHGRI 5R01HG002939 (A.F.A.S. and R.H.), NIH NHGRI 5U24HG010136 (A.F.A.S. and R.H.), NIH NHGRI 5R01HG010485 (B.P. and M.D.), NIH NHGRI 2U41HG007234 (B.P., M.D. and J. Armstrong), NIH NIA 5PO1AG047200 (V.N.G.), NIH NIA 1UH2AG064706 (V.N.G.), BFU2017-86471-P MINECO/FEDER, UE (T.M.-B.), Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya GRC 2017 SGR 880 (T.M.-B.), Howard Hughes International Early Career (T.M.-B.), European Research Council Horizon 2020 no. 864203 (T.M.-B.), Obra Social ‘La Caixa’ (T.M.-B.), BBSRC BBS/E/T/000PR9818, BBS/E/T/ 000PR9783 (W.H. and W.N.), BBSRC Core Strategic Programme Grant BB/P016774/1 (W.H., W.N. and F.D.), Sir Henry Dale Fellowship 200517/Z/16/Z jointly funded by the Wellcome Trust and the Royal Society (N.R.C.), FJCI-2016-29558 MICINN (D.J.), Prince Albert II Foundation of Monaco and Canada, Global Genome Initiative, Smithsonian Institution (M.N.), European Research Council Research Grant ERC-2012-StG311000 (E.C.T.), Irish Research Council Laureate Award (E.C.T.), UK Medical Research Council MR/P026028/1 (W.H. and W.N.), National Science Foundation DEB-1457735 (M.S.S.), National Science Foundation DEB-1753760 (W.J.M.), National Science Foundation IOS-2029774 (E.K.K. and D.P.G.), Robert and Rosabel Osborne Endowment (H.A.L. and J.D.), Swedish Research Council, FORMAS 221-2012-1531 (J.R.S.M.), NSF RoL: FELS: EAGER: DEB 1838283 (D.A.R.) and Academy of Finland grant to Center of Excellence in Tumor Genetics Research no. 312042 (T.K. and J.T.). 2021-03-25T15:40:10Z 2021-03-25T15:40:10Z 2020-11-12 2021-03-25T15:40:10Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1038/s41586-020-2876-6 e-issn: 1476-4687 issn: 0028-0836 Nature 587: 240-245 (2020) http://hdl.handle.net/10261/236047 10.1038/s41586-020-2876-6 http://dx.doi.org/10.13039/501100002081 http://dx.doi.org/10.13039/501100004063 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100000288 http://dx.doi.org/10.13039/100000014 http://dx.doi.org/10.13039/100000011 http://dx.doi.org/10.13039/100004440 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100002341 http://dx.doi.org/10.13039/501100007051 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-86471-P BFU2017-86471-P/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/EC/H2020/864203 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FJCI-2016-29558 Publisher's version http://dx.doi.org/10.1038/s41586-020-2876-6 Sí open Nature Publishing Group |