Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptation

To shed light on the peopling of South Asia and the origins of the morphological adaptations found there, we analyzed whole-genome sequences from 10 Andamanese individuals and compared them with sequences for 60 individuals from mainland Indian populations with different ethnic histories and with publicly available data from other populations. We show that all Asian and Pacific populations share a single origin and expansion out of Africa, contradicting an earlier proposal of two independent waves of migration1, 2, 3, 4. We also show that populations from South and Southeast Asia harbor a small proportion of ancestry from an unknown extinct hominin, and this ancestry is absent from Europeans and East Asians. The footprints of adaptive selection in the genomes of the Andamanese show that the characteristic distinctive phenotypes of this population (including very short stature) do not reflect an ancient African origin but instead result from strong natural selection on genes related to human body size.

Bibliographic Details

Main Authors:	Mondal, Mayukh, Casals, Ferran, Xu, Tina, Dall'Olio, Giovanni Marco, Pybus, Marc, Netea, Mihai G., Comas, David, Laayouni, Hafid, Li, Qibin, Majumder, Partha P., Bertranpetit, Jaume
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	http://hdl.handle.net/10261/151659 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100002809
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