Evaluating intra- and inter-individual variation in the human placental transcriptome

[Background] Gene expression variation is a phenotypic trait of particular interest as it represents the initial link between genotype and other phenotypes. Analyzing how such variation apportions among and within groups allows for the evaluation of how genetic and environmental factors influence such traits. It also provides opportunities to identify genes and pathways that may have been influenced by non-neutral processes. Here we use a population genetics framework and next generation sequencing to evaluate how gene expression variation is apportioned among four human groups in a natural biological tissue, the placenta.

Bibliographic Details

Main Authors:	Hughes, David A., Kircher, Martin, He, Zhisong, Guo, Song, Fairbrother, Genevieve L., Moreno, Carlos S., Khaitovich, Philipp, Stoneking, Mark
Other Authors:	Max Planck Society
Format:	artículo biblioteca
Language:	English
Published:	BioMed Central 2015-03-19
Online Access:	http://hdl.handle.net/10261/151389 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/501100002367
Tags:	Add Tag No Tags, Be the first to tag this record!