Baseline Brain Perfusion and the Serotonin Transporter Promoter Polymorphism
[Background] The serotonin transporter length repeat polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) has been associated in healthy subjects with changes in basal perfusion levels in the limbic system and ventral prefrontal areas, regions involved in the pathophysiology of depression and anxiety, suggesting the existence of a neurobiological trait predisposing to these disorders. We reassess the findings of an increased baseline perfusion in the amygdala and ventral prefrontal areas in healthy carriers of the risk genotype in a much larger sample than in previous studies.
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | artículo biblioteca |
| Published: |
Elsevier
2010-02-15
|
| Subjects: | Amygdala, Depression, Serotonin transporter, 5-HTTLPR polymorphism, Orbitofrontal cortex, Brain perfusion, |
| Online Access: | http://hdl.handle.net/10261/111633 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|