Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions.

Bibliographic Details

Main Authors:	Mariani, Nicole, Borsini, Alessandra, Cecil, Charlotte A M, Felix, Janine F, Sebert, Sylvain, Cattaneo, Annamaria, Walton, Esther, Milaneschi, Yuri, Cochrane, Guy, Amid, Clara, Rajan, Jeena, Giacobbe, Juliette, Sanz Herranz, Yolanda, Agustí, Ana, Sorg, Tania, Herault, Yann, Miettunen, Jouko, Parmar, Priyanka, Cattane, Nadia, Jaddoe, Vincent, Lötjönen, Jyrki, Buisan, Carme, González Ballester, Miguel A, Piella, Gemma, Gelpí, Josep Lluis, Lamers, Femke, Penninx, Brenda W. J. H., Tiemeier, Henning, von Tottleben, Malte, Thiel, Rainer, Heil, Katharina F, Järvelin, Marjo-Riitta, Pariante, Carmine, Mansuy, Isabelle M, Lekadir, Karim
Other Authors:	European Commission
Format:	artículo biblioteca
Language:	English
Published:	Public Library of Science 2021-01
Subjects:	Microbiome, Medical risk factors, Biomarkers, Epigenetics, Psychological stress, Depression, Human genetics, Metabolic pathways,
Online Access:	http://hdl.handle.net/10261/257820 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85100195886
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