Detection Of Genomic Variants Of SARS-CoV-2 Circulating In Wastewater By High-Throughput Sequencing

Detection Of Genomic Variants Of SARS-CoV-2 Circulating In Wastewater By High-Throughput Sequencing

The use of SARS-CoV-2 metagenomics in wastewater can allow the detection of variants circulating at community level. After comparing with clinical databases, we identified three novel variants in the spike gene, and six new variants in the spike detected for the first time in Spain. We finally support the hypothesis that this approach allows the identification of unknown SARS-CoV-2 variants or detected at only low frequencies in clinical genomes.

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Bibliographic Details
Main Authors: Pérez Cataluña, Alba, Chiner-Oms, Álvaro, Cuevas Ferrando, Enric, Díaz-Reolid, Azahara, Falcó, Irene, Randazzo, Walter, Girón-Guzmán, Inés, Allende, Ana, Bracho, María Alma, Comas, Iñaki, Sánchez Moragas, Gloria
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: preprint biblioteca
Language:English
Published: MedRxiv 2021-02-10
Online Access:http://hdl.handle.net/10261/229251
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100000780
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http://hdl.handle.net/10261/229251
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100000780

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