Unravelling the origin of SARS-CoV-2: is the model good?
MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.
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| Main Authors: | , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | coronavirus 2 du syndrome respiratoire aigu sévère, covid-19, Chiroptera, zoonose, transmission des maladies, modélisation, genre humain, http://aims.fao.org/aos/agrovoc/c_365a18ab, http://aims.fao.org/aos/agrovoc/c_4ad07701, http://aims.fao.org/aos/agrovoc/c_1560, http://aims.fao.org/aos/agrovoc/c_8530, http://aims.fao.org/aos/agrovoc/c_2329, http://aims.fao.org/aos/agrovoc/c_230ab86c, http://aims.fao.org/aos/agrovoc/c_4586, |
| Online Access: | http://agritrop.cirad.fr/605904/ http://agritrop.cirad.fr/605904/1/ID605904.pdf |
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