High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy
Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95%CI [1.01–1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | article biblioteca |
Language: | eng |
Subjects: | malaria, femme enceinte, parturition, enfant, immunité maternelle, tolérance immunitaire, vecteur de maladie, piqûre d'insecte, http://aims.fao.org/aos/agrovoc/c_34312, http://aims.fao.org/aos/agrovoc/c_331411, http://aims.fao.org/aos/agrovoc/c_5604, http://aims.fao.org/aos/agrovoc/c_1547, http://aims.fao.org/aos/agrovoc/c_12430, http://aims.fao.org/aos/agrovoc/c_29610, http://aims.fao.org/aos/agrovoc/c_8164, http://aims.fao.org/aos/agrovoc/c_11789, http://aims.fao.org/aos/agrovoc/c_6970, http://aims.fao.org/aos/agrovoc/c_875, |
Online Access: | http://agritrop.cirad.fr/593018/ http://agritrop.cirad.fr/593018/1/Publi%20High%20level%20HLA_G%20as%20predictor%20of%20malaria%20risk%20during%20Pregnancy%20SR_2019.pdf |
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