Michael reactions carried out using a bench-top flow system
The Michael reaction between methyl 1-oxoindan-2-carboxylate and methyl vinyl ketone was achieved successfully by pumping solutions of the reactants in toluene through a fluid bed of Amberlyst A21 at 50 °C. The use of a fluid bed reactor is attractive as it allows gel-type beads, i.e. the type of bead used in most studies of polymer-supported (PS) organic reactions, to be used satisfactorily in a flow system. When polymer-supported cinchonidine was used in place of Amberlyst A21, the Michael product was obtained in high yield with an enantiomeric excess (ee) of 51%. This % ee is comparable to that achieved when the reaction was catalysed by cinchonidine itself.
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| Main Authors: | , , , |
|---|---|
| Format: | article biblioteca |
| Language: | eng |
| Subjects: | 000 - Autres thèmes, Q60 - Traitement des produits agricoles non alimentaires, |
| Online Access: | http://agritrop.cirad.fr/578155/ http://agritrop.cirad.fr/578155/1/Michael%20reactions%20carried%20out%20using%20a%20bench-top%20flow%20system.pdf |
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