A large-scale genomic approach affords unprecedented resolution for the molecular epidemiology and evolutionary history of contagious caprine pleuropneumonia
Background: Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae (Mccp), is a devastating disease of domestic goats and of some wild ungulate species. The disease is currently spreading in Africa and Asia and poses a serious threat to disease-free areas. A comprehensive view of the evolutionary history and dynamics of Mccp is essential to understand the epidemiology of CCPP. Yet, analysing the diversity of genetically monomorphic pathogens, such as Mccp, is complicated due to their low variability. Objectives: In this study we investigated the molecular epidemiology and evolution of CCPP using a large-scale genomic approach. Methods: Next-generation sequencing data was used to develop a highly discriminatory multigene typing system, applied to a sample of strains representing the global distribution of CCPP. A Bayesian approach was used to infer the first robust phylogeny of Mccp and to date the principal events of its evolutionary history. Conclusions: This study shows how combining large-scale genomic data with spatial and temporal data makes it possible to obtain a comprehensive view of the epidemiology of CCPP, a precondition for the development of improved disease surveillance and control measures. (Texte intégral)
| Main Authors: | , , |
|---|---|
| Format: | conference_item biblioteca |
| Language: | eng |
| Published: |
Pendik Veterinary Control Institute
|
| Subjects: | L73 - Maladies des animaux, |
| Online Access: | http://agritrop.cirad.fr/576262/ http://agritrop.cirad.fr/576262/1/eMLST_Mccp_Pendik_final.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|