Heterologous production of Albicidin : a promising approach to overproducing and characterizing this potent inhibitor of DNA Gyrase
The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.
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| Main Authors: | , , , , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | H20 - Maladies des plantes, |
| Online Access: | http://agritrop.cirad.fr/541558/ http://agritrop.cirad.fr/541558/1/document_541558.pdf |
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