Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants

Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants

The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved.

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Main Authors: Perrin, Aurélie, Albina, Emmanuel, Breard, Emmanuel, Sailleau, Corinne, Prome, Sylvie, Grillet, Colette, Kwiatek, Olivier, Russo, Pierre, Thiéry, Richard, Zientara, Stéphan, Cetre-Sossah, Catherine
Format: article biblioteca
Language:eng
Subjects:L73 - Maladies des animaux,
Online Access:http://agritrop.cirad.fr/540927/
http://agritrop.cirad.fr/540927/1/document_540927.pdf
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spelling dig-cirad-fr-5409272021-02-26T12:39:20Z http://agritrop.cirad.fr/540927/ http://agritrop.cirad.fr/540927/ Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants. Perrin Aurélie, Albina Emmanuel, Breard Emmanuel, Sailleau Corinne, Prome Sylvie, Grillet Colette, Kwiatek Olivier, Russo Pierre, Thiéry Richard, Zientara Stéphan, Cetre-Sossah Catherine. 2007. Vaccine, 25 : 6774-6783.https://doi.org/10.1016/j.vaccine.2007.06.052 <https://doi.org/10.1016/j.vaccine.2007.06.052> Researchers Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants Perrin, Aurélie Albina, Emmanuel Breard, Emmanuel Sailleau, Corinne Prome, Sylvie Grillet, Colette Kwiatek, Olivier Russo, Pierre Thiéry, Richard Zientara, Stéphan Cetre-Sossah, Catherine eng 2007 Vaccine L73 - Maladies des animaux The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/540927/1/document_540927.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1016/j.vaccine.2007.06.052 10.1016/j.vaccine.2007.06.052 http://catalogue-bibliotheques.cirad.fr/cgi-bin/koha/opac-detail.pl?biblionumber=184418 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vaccine.2007.06.052 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.vaccine.2007.06.052
institution CIRAD FR
collection DSpace
country Francia
countrycode FR
component Bibliográfico
access En linea
databasecode dig-cirad-fr
tag biblioteca
region Europa del Oeste
libraryname Biblioteca del CIRAD Francia
language eng
topic L73 - Maladies des animaux
L73 - Maladies des animaux
spellingShingle L73 - Maladies des animaux
L73 - Maladies des animaux
Perrin, Aurélie
Albina, Emmanuel
Breard, Emmanuel
Sailleau, Corinne
Prome, Sylvie
Grillet, Colette
Kwiatek, Olivier
Russo, Pierre
Thiéry, Richard
Zientara, Stéphan
Cetre-Sossah, Catherine
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
description The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved.
format article
topic_facet L73 - Maladies des animaux
author Perrin, Aurélie
Albina, Emmanuel
Breard, Emmanuel
Sailleau, Corinne
Prome, Sylvie
Grillet, Colette
Kwiatek, Olivier
Russo, Pierre
Thiéry, Richard
Zientara, Stéphan
Cetre-Sossah, Catherine
author_facet Perrin, Aurélie
Albina, Emmanuel
Breard, Emmanuel
Sailleau, Corinne
Prome, Sylvie
Grillet, Colette
Kwiatek, Olivier
Russo, Pierre
Thiéry, Richard
Zientara, Stéphan
Cetre-Sossah, Catherine
author_sort Perrin, Aurélie
title Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
title_short Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
title_full Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
title_fullStr Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
title_full_unstemmed Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
title_sort recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
url http://agritrop.cirad.fr/540927/
http://agritrop.cirad.fr/540927/1/document_540927.pdf
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