Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved.
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dig-cirad-fr-5409272021-02-26T12:39:20Z http://agritrop.cirad.fr/540927/ http://agritrop.cirad.fr/540927/ Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants. Perrin Aurélie, Albina Emmanuel, Breard Emmanuel, Sailleau Corinne, Prome Sylvie, Grillet Colette, Kwiatek Olivier, Russo Pierre, Thiéry Richard, Zientara Stéphan, Cetre-Sossah Catherine. 2007. Vaccine, 25 : 6774-6783.https://doi.org/10.1016/j.vaccine.2007.06.052 <https://doi.org/10.1016/j.vaccine.2007.06.052> Researchers Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants Perrin, Aurélie Albina, Emmanuel Breard, Emmanuel Sailleau, Corinne Prome, Sylvie Grillet, Colette Kwiatek, Olivier Russo, Pierre Thiéry, Richard Zientara, Stéphan Cetre-Sossah, Catherine eng 2007 Vaccine L73 - Maladies des animaux The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/540927/1/document_540927.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1016/j.vaccine.2007.06.052 10.1016/j.vaccine.2007.06.052 http://catalogue-bibliotheques.cirad.fr/cgi-bin/koha/opac-detail.pl?biblionumber=184418 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vaccine.2007.06.052 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.vaccine.2007.06.052 |
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L73 - Maladies des animaux L73 - Maladies des animaux Perrin, Aurélie Albina, Emmanuel Breard, Emmanuel Sailleau, Corinne Prome, Sylvie Grillet, Colette Kwiatek, Olivier Russo, Pierre Thiéry, Richard Zientara, Stéphan Cetre-Sossah, Catherine Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
description |
The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved. |
format |
article |
topic_facet |
L73 - Maladies des animaux |
author |
Perrin, Aurélie Albina, Emmanuel Breard, Emmanuel Sailleau, Corinne Prome, Sylvie Grillet, Colette Kwiatek, Olivier Russo, Pierre Thiéry, Richard Zientara, Stéphan Cetre-Sossah, Catherine |
author_facet |
Perrin, Aurélie Albina, Emmanuel Breard, Emmanuel Sailleau, Corinne Prome, Sylvie Grillet, Colette Kwiatek, Olivier Russo, Pierre Thiéry, Richard Zientara, Stéphan Cetre-Sossah, Catherine |
author_sort |
Perrin, Aurélie |
title |
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
title_short |
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
title_full |
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
title_fullStr |
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
title_full_unstemmed |
Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
title_sort |
recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants |
url |
http://agritrop.cirad.fr/540927/ http://agritrop.cirad.fr/540927/1/document_540927.pdf |
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