Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants
The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved.
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| Main Authors: | , , , , , , , , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | L73 - Maladies des animaux, |
| Online Access: | http://agritrop.cirad.fr/540927/ http://agritrop.cirad.fr/540927/1/document_540927.pdf |
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