Production of alpha interferon in Cowdria ruminantium infected cattle and its effect on infected endothelial cell cultures
Cattle that resisted experimental heatntwater infection caused by the rickettsia #Cowdria ruminantium# produced significant levels of circulating alpha-interferon (IFN-alpha) whereas animals that died from heartwater did not. #In vitro#, recombinant bovine IFN.alpha) was found to significantly reduce the yield of #Cowdria# organisms in bovine endothelial cells, but even at a high concentration (1,000 U/ml), IFN-alpha did not completely prevent the growth of #Cowdria# organisms in these cells. This limited inhibitory effect of IFN-alpha is in agreement with the #in vivo# situation where an infectious process has to take place to induce a protective immune response. Our results suggest that IFN-alpha produced #in vivo# in response to #Cowdria# infection may represent an efficient way to slow down the infection and allow the animal to mount a protective immune response. IFN-alpha is the first endogenously produced factor shown to have anti-#Cowdria# activity.
| Main Authors: | , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | L73 - Maladies des animaux, bovin, Ehrlichia ruminantium, interféron, http://aims.fao.org/aos/agrovoc/c_1391, http://aims.fao.org/aos/agrovoc/c_34694, http://aims.fao.org/aos/agrovoc/c_3914, |
| Online Access: | http://agritrop.cirad.fr/389745/ |
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