Exploring the modulatory effect of trehalose-derived galactooligosaccharides on key gut microbiota groups

Trehalose (α-d-glucopyranosyl-(1-1)-α-D-glucopyranoside) has found applications in diverse food products as a sweetener, stabilizer, and humectant. Recent attention has focused on trehalose due to its contradictory effects on the virulence of Clostridium difficile. In this study, we investigate the impact of novel trehalose-derived galactooligosaccharides (Treh-GOS) on the human gut microbiota using in vitro fecal fermentation models. Distinct Treh-GOS structures elicit varying taxonomic responses. For instance, β-Gal-(1-4)-trehalose [DP3(1-4)] leads to an increase of Bifidobacterium, comparable to results observed with commercial GOS. Conversely, β-Gal-(1-6)-trehalose [DP3(1-6)] prompts an increase in Lactobacillus. Notably, both of these trisaccharides yield the highest concentrations of butyric acid across all samples. On the other hand, Treh-GOS tetrasaccharide mixture (DP4), featuring a novel trehalose galactosylation in both glucose units, fosters the growth of Parabacteroides. Our findings underscore the capacity of novel Treh-GOS to modulate the human gut microbiota. Consequently, these innovative galactooligosaccharides emerge as promising candidates for novel prebiotic applications.

Bibliographic Details

Main Authors:	Calvete-Torre, Inés, Sabater, Carlos, Villamiel, Mar, Margolles Barros, Abelardo, Méndez-Albiñana, Pablo, Ruiz, Lorena, Hernández-Hernández, Oswaldo
Other Authors:	Agencia Estatal de Investigación (España)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2024-07
Subjects:	Galactooligosaccharides, Microbiota, Prebiotics, Trehalose,
Online Access:	http://hdl.handle.net/10261/371912 https://api.elsevier.com/content/abstract/scopus_id/85196011314
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