Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients

Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients

[Scope] This paper explores the effects of moderate red wine consumption on the clinical status and symptomatology of patients with ulcerative colitis (UC), including the study of the oral and intestinal microbiome.

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Main Authors: Taladrid, Diego, Zorraquín-Peña, Irene, Molinero, Natalia, Manceñido, Noemí, Pajares, Ramón, Bartolomé, Begoña, Moreno-Arribas, M. Victoria
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Wiley-VCH 2022
Online Access:http://hdl.handle.net/10261/303013
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spelling dig-cial-es-10261-3030132023-03-13T13:53:29Z Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients Taladrid, Diego Zorraquín-Peña, Irene Molinero, Natalia Manceñido, Noemí Pajares, Ramón Bartolomé, Begoña Moreno-Arribas, M. Victoria Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Comunidad de Madrid Bodegas Torres [Scope] This paper explores the effects of moderate red wine consumption on the clinical status and symptomatology of patients with ulcerative colitis (UC), including the study of the oral and intestinal microbiome. [Methods and results] A case control intervention study in UC patients is designed. Intervention patients (n = 5) consume red wine (250 mL day−1) for 4 weeks whereas control patients (n = 5) do not. Moderate wine consumption significantly (p < 0.05) improves some clinical parameters related to serum iron, and alleviates intestinal symptoms as evaluated by the IBDQ-32 questionnaire. 16S rRNA gene sequencing indicate a non-significant (p > 0.05) increase in bacterial alpha diversity after wine intervention in both saliva and fecal microbiota. Additional comparison of taxonomic data between UC patients (n = 10) and healthy subjects (n = 8) confirm intestinal dysbiosis for the UC patients. Finally, analysis of fecal metabolites (i.e., phenolic acids and SCFAs) indicates a non-significant increase (p > 0.05) for the UC patients that consumed wine. [Conclusions] Moderate and regular red wine intake seems to improve the clinical status and symptoms of UC patients in the active phase of the disease. However, studies with a greater sample size are required to achieve conclusive results. Research in our labs is funded by Grants AGL2015-64522-C2-R and PID2019-108851RB-C21 (Spanish Ministry of Science and Innovation), and ALIBIRD-CM 2020 P2018/BAA-4343 (Comunidad de Madrid, Spain). The authors would like to thank Bodegas Miguel Torres S.L. for providing the red wine. I.Z-P. is grateful for the BES-2016-077980 contract. Peer reviewed 2023-03-13T13:53:28Z 2023-03-13T13:53:28Z 2022 artículo Molecular Nutrition and Food Research 66(21): 2101073 (2022) http://hdl.handle.net/10261/303013 10.1002/mnfr.202101073 1613-4133 35633101 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//AGL2015-64522-C2-2-R/ES/POLIFENOLES Y METABOLITOS. ESTUDIO EN C. ELEGANS DE SUS MECANISMOS DE ACCION Y RELACION CON LA MICROBIOTA/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108851RB-C21/ES/RELACION ENTRE EL CONSUMO DE VINO, LA DIETA Y LA MODULACION DEL MICROBIOMA EN LA ENFERMEDAD DE ALZHEIMER EN UNA COHORTE DE MADRID (ESPAÑA)/ P2018/BAA-4343/ALIBIRD-CM info:eu-repo/grantAgreement/MINECO//BES-2016-077980 Molecular Nutrition and Food Research Publisher's version https://doi.org/10.1002/mnfr.202101073 Sí open application/pdf Wiley-VCH
institution CIAL ES
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country España
countrycode ES
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libraryname Biblioteca del CIAL España
language English
description [Scope] This paper explores the effects of moderate red wine consumption on the clinical status and symptomatology of patients with ulcerative colitis (UC), including the study of the oral and intestinal microbiome.
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Taladrid, Diego
Zorraquín-Peña, Irene
Molinero, Natalia
Manceñido, Noemí
Pajares, Ramón
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
format artículo
author Taladrid, Diego
Zorraquín-Peña, Irene
Molinero, Natalia
Manceñido, Noemí
Pajares, Ramón
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
spellingShingle Taladrid, Diego
Zorraquín-Peña, Irene
Molinero, Natalia
Manceñido, Noemí
Pajares, Ramón
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
author_sort Taladrid, Diego
title Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
title_short Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
title_full Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
title_fullStr Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
title_full_unstemmed Polyphenols and ulcerative colitis: An exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
title_sort polyphenols and ulcerative colitis: an exploratory study of the effects of red wine consumption on gut and oral microbiome in active-phase patients
publisher Wiley-VCH
publishDate 2022
url http://hdl.handle.net/10261/303013
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