Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori

Villalva, Marisol; Silván, José Manuel; Guerrero-Hurtado, Esperanza; Gutiérrez-Docio, Alba; Navarro del Hierro, Joaquín; Alarcón, Teresa; Prodanov, M.; Martín, Diana; Martínez-Rodríguez, Adolfo J.; Ministerio de Ciencia, Innovación y Universidades (España)

Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori

This article belongs to the Special Issue Innovative Research on Food Bioactive Compounds Using In Vitro Digestion Models.

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Main Authors:	Villalva, Marisol, Silván, José Manuel, Guerrero-Hurtado, Esperanza, Gutiérrez-Docio, Alba, Navarro del Hierro, Joaquín, Alarcón, Teresa, Prodanov, M., Martín, Diana, Martínez-Rodríguez, Adolfo J.
Other Authors:	Ministerio de Ciencia, Innovación y Universidades (España)
Format:	artículo biblioteca
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2022
Subjects:	Gastric digestion, Olive leaf extract, Helicobacter pylori, Anti-inflammatory activity, Antioxidant activity, HPLC-PAD-MS characterization, Antibacterial activity,
Online Access:	http://hdl.handle.net/10261/279190 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329
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spelling	dig-cial-es-10261-2791902022-11-04T17:32:12Z Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori Villalva, Marisol Silván, José Manuel Guerrero-Hurtado, Esperanza Gutiérrez-Docio, Alba Navarro del Hierro, Joaquín Alarcón, Teresa Prodanov, M. Martín, Diana Martínez-Rodríguez, Adolfo J. Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Ministerio de Economía y Competitividad (España) Comunidad de Madrid Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity This article belongs to the Special Issue Innovative Research on Food Bioactive Compounds Using In Vitro Digestion Models. The aim of this work was to evaluate the influence of in vitro gastric digestion of two olive leaf extracts (E1 and E2) on their chemical composition and bioactive properties against Helicobacter pylori (H. pylori), one of the most successful and prevalent human pathogens. HPLC-PAD/MS analysis and anti-inflammatory, antioxidant, and antibacterial activities of both olive leaf extracts were carried out before and after their in vitro gastric digestion. The results showed that gastric digestion produced modifications of the chemical composition and bioactive properties of both olive leaf extracts. The main compounds in the extract E1 were hydroxytyrosol and its glucoside derivatives (14,556 mg/100 g), presenting all the identified compounds a more polar character than those found in the E2 extract. E2 showed a higher concentration of less polar compounds than E1 extract, with oleuropein (21,419 mg/100 g) being the major component. Gastric digestion during the fasted state (pH 2) induced an overall decrease of the most identified compounds. In the extract E1, while the anti-inflammatory capacity showed only a slight decrease (9% of IL-8 production), the antioxidant properties suffered a drastic drop (23% of ROS inhibition), as well as the antibacterial capacity. However, in the extract E2, these changes caused an increase in the anti-inflammatory (19% of IL-8 production) and antioxidant activity (9% of ROS inhibition), which could be due to the hydrolysis of oleuropein and ligustroside into their main degradation products, hydroxytyrosol and tyrosol, but the antibacterial activity was reduced. Gastric digestion during fed state (pH 5) had less influence on the composition of the extracts, affecting in a lesser degree their anti-inflammatory and antioxidant activity, although there was a decrease in the antibacterial activity in both extracts similar to that observed at pH 2. This research was funded by MINECO (Spain), Project HELIFOOD (AGL2017-89566-R). Esperanza Guerrero-Hurtado thanks Consejería de Educación e Investigación from Comunidad de Madrid for the financial support of contract IND2019/BIO-17238. The authors thank Soledad Diaz Palero for experimental support (Garantía Juvenil CAM 2020, Ref. 37722). Peer reviewed 2022-09-15T09:40:45Z 2022-09-15T09:40:45Z 2022 artículo Foods 11(13): 1832 (2022) http://hdl.handle.net/10261/279190 10.3390/foods11131832 2304-8158 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 35804647 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89566-R/ES/REVALORIZACION DE SUBPRODUCTOS DE LA INDUSTRIA ALIMENTARIA COMO FUENTE DE COMPUESTOS BIOACTIVOS UTILES PARA LA MITIGACION DE LA INFECCION HUMANA POR HELICOBACTER PYLORI/ Publisher's version https://doi.org/10.3390/foods11131832 Sí open Multidisciplinary Digital Publishing Institute
institution	CIAL ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-cial-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del CIAL España
language	English
topic	Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity
spellingShingle	Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity Villalva, Marisol Silván, José Manuel Guerrero-Hurtado, Esperanza Gutiérrez-Docio, Alba Navarro del Hierro, Joaquín Alarcón, Teresa Prodanov, M. Martín, Diana Martínez-Rodríguez, Adolfo J. Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
description	This article belongs to the Special Issue Innovative Research on Food Bioactive Compounds Using In Vitro Digestion Models.
author2	Ministerio de Ciencia, Innovación y Universidades (España)
author_facet	Ministerio de Ciencia, Innovación y Universidades (España) Villalva, Marisol Silván, José Manuel Guerrero-Hurtado, Esperanza Gutiérrez-Docio, Alba Navarro del Hierro, Joaquín Alarcón, Teresa Prodanov, M. Martín, Diana Martínez-Rodríguez, Adolfo J.
format	artículo
topic_facet	Gastric digestion Olive leaf extract Helicobacter pylori Anti-inflammatory activity Antioxidant activity HPLC-PAD-MS characterization Antibacterial activity
author	Villalva, Marisol Silván, José Manuel Guerrero-Hurtado, Esperanza Gutiérrez-Docio, Alba Navarro del Hierro, Joaquín Alarcón, Teresa Prodanov, M. Martín, Diana Martínez-Rodríguez, Adolfo J.
author_sort	Villalva, Marisol
title	Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
title_short	Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
title_full	Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
title_fullStr	Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
title_full_unstemmed	Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori
title_sort	influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against h. pylori
publisher	Multidisciplinary Digital Publishing Institute
publishDate	2022
url	http://hdl.handle.net/10261/279190 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329
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_version_	1777671555361275904

Influence of in vitro gastric digestion of olive leaf extracts on their bioactive properties against H. pylori

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