Antiviral properties of supercritical CO2 extracts from oregano and sage
The antiviral properties of supercritical CO2 extracts obtained from oregano and sage were evaluated against the herpes simplex virus type 1 at different stages during virus infection. All of the extracts tested presented a moderate extracellular direct virucidal activity, although a pre-treatment of Vero cells, with 10 μg/mL of sage extracts before virus addition, inhibited 70% of the virus infection. Moreover, supercritical extracts of sage and oregano were able to significantly inhibit the in vitro virus replication, showing IC50 values of 1.88 and 5.33 μg/mL, respectively. Carvacrol and thymol could be pointed out as the compounds responsible for the antiviral activity found in oregano supercritical extracts; meanwhile, borneol, camphor, and 1,8-cineole could be proposed as antiviral compounds in supercritical sage extracts. Results demonstrated that supercritical extraction was an appropriate technique to obtain antiviral extracts from oregano and sage.
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Taylor & Francis
2014
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| Online Access: | http://hdl.handle.net/10261/241044 http://dx.doi.org/10.13039/100012818 |
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