In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek was performed. Production of sapogenins by human fecal microbiota and the impact of extracts on representative intestinal bacterial groups were evaluated. The main sapogenins were found after fermentation (soyasapogenol B for lentil; oleanolic acid, hederagenin, phytolaccagenic acid, and serjanic acid for quinoa; and sarsasapogenin, diosgenin, and neotigogenin acetate for fenugreek). Interindividual differences were observed, but the highest production of sapogenins corresponded to quinoa (90 μg/mL) and fenugreek (70 μg/mL) extracts, being minor for lentil (4 μg/mL). Lentil and quinoa extracts showed a general antimicrobial effect, mainly on lactic acid bacteria and Lactobacillus spp. Significant increases of Bifidobacterium spp. and Lactobacillus spp. were observed for fenugreek in one volunteer. Thus, the transformation of saponin-rich extracts of quinoa, lentil, and fenugreek to sapogenins by human gut microbiota is demonstrated, exhibiting a modulatory effect on the growth of selected intestinal bacteria.
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Language: | English |
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American Chemical Society
2020
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Subjects: | Saponins, Gut microbiota, Sapogenins, Diosgenin, Soyasapogenol, Oleanolic acid, |
Online Access: | http://hdl.handle.net/10261/220143 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/100012818 |
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dig-cial-es-10261-2201432020-09-25T01:14:49Z In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota Navarro del Hierro, Joaquín Cueva, Carolina Tamargo García, Alba Núñez-Gómez, Estefanía Moreno-Arribas, M. Victoria Reglero, Guillermo Martín, Diana Ministerio de Economía y Competitividad (España) Comunidad de Madrid Ministerio de Educación, Cultura y Deporte (España) Moreno-Arribas, M. Victoria [0000-0002-4136-595X] Martín, Diana [0000-0002-1082-9280] Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek was performed. Production of sapogenins by human fecal microbiota and the impact of extracts on representative intestinal bacterial groups were evaluated. The main sapogenins were found after fermentation (soyasapogenol B for lentil; oleanolic acid, hederagenin, phytolaccagenic acid, and serjanic acid for quinoa; and sarsasapogenin, diosgenin, and neotigogenin acetate for fenugreek). Interindividual differences were observed, but the highest production of sapogenins corresponded to quinoa (90 μg/mL) and fenugreek (70 μg/mL) extracts, being minor for lentil (4 μg/mL). Lentil and quinoa extracts showed a general antimicrobial effect, mainly on lactic acid bacteria and Lactobacillus spp. Significant increases of Bifidobacterium spp. and Lactobacillus spp. were observed for fenugreek in one volunteer. Thus, the transformation of saponin-rich extracts of quinoa, lentil, and fenugreek to sapogenins by human gut microbiota is demonstrated, exhibiting a modulatory effect on the growth of selected intestinal bacteria. This work was supported by the Ministerio de Economía y Competitividad, Spain (AGL2016-76736-C3-1-R; AGL2015-64522-C2-1-R) and the Community of Madrid, Spain (ALIBIRD2020-CM, S2018/BAA-4343). J.N.d.H. thanks the Ministerio de Educacion, Cultura y Deporte for funding his research with a FPU predoctoral contract (FPU 15/04236). Peer reviewed 2020-09-24T06:55:04Z 2020-09-24T06:55:04Z 2020 artículo http://purl.org/coar/resource_type/c_6501 Journal of Agricultural and Food Chemistry 68(1): 106–116 (2020) 0021-8561 http://hdl.handle.net/10261/220143 10.1021/acs.jafc.9b05659 1520-5118 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/100012818 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76736-C3-1-R info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64522-C2-1-R S2018/BAA-4343/ALIBIRD2020-CM https://doi.org/10.1021/acs.jafc.9b05659 Sí none American Chemical Society |
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Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid |
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Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid Navarro del Hierro, Joaquín Cueva, Carolina Tamargo García, Alba Núñez-Gómez, Estefanía Moreno-Arribas, M. Victoria Reglero, Guillermo Martín, Diana In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
description |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek was performed. Production of sapogenins by human fecal microbiota and the impact of extracts on representative intestinal bacterial groups were evaluated. The main sapogenins were found after fermentation (soyasapogenol B for lentil; oleanolic acid, hederagenin, phytolaccagenic acid, and serjanic acid for quinoa; and sarsasapogenin, diosgenin, and neotigogenin acetate for fenugreek). Interindividual differences were observed, but the highest production of sapogenins corresponded to quinoa (90 μg/mL) and fenugreek (70 μg/mL) extracts, being minor for lentil (4 μg/mL). Lentil and quinoa extracts showed a general antimicrobial effect, mainly on lactic acid bacteria and Lactobacillus spp. Significant increases of Bifidobacterium spp. and Lactobacillus spp. were observed for fenugreek in one volunteer. Thus, the transformation of saponin-rich extracts of quinoa, lentil, and fenugreek to sapogenins by human gut microbiota is demonstrated, exhibiting a modulatory effect on the growth of selected intestinal bacteria. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) Navarro del Hierro, Joaquín Cueva, Carolina Tamargo García, Alba Núñez-Gómez, Estefanía Moreno-Arribas, M. Victoria Reglero, Guillermo Martín, Diana |
format |
artículo |
topic_facet |
Saponins Gut microbiota Sapogenins Diosgenin Soyasapogenol Oleanolic acid |
author |
Navarro del Hierro, Joaquín Cueva, Carolina Tamargo García, Alba Núñez-Gómez, Estefanía Moreno-Arribas, M. Victoria Reglero, Guillermo Martín, Diana |
author_sort |
Navarro del Hierro, Joaquín |
title |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
title_short |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
title_full |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
title_fullStr |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
title_full_unstemmed |
In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota |
title_sort |
in vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. effect on sapogenins yield and human gut microbiota |
publisher |
American Chemical Society |
publishDate |
2020 |
url |
http://hdl.handle.net/10261/220143 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/100012818 |
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