Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer

Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer

This article belongs to the Special Issue Dietary Patterns, Dietary Indices for Colorectal Cancer, Mortality and the Related Disease.

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Bibliographic Details
Main Authors: Cueva, Carolina, Silva, Mariana, Pinillos, Iris, Bartolomé, Begoña, Moreno-Arribas, M. Victoria
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Subjects:Colorectal cancer, Oral microbiota, Gut microbiota, Dysbiosis, Diet, Polyphenol metabolites,
Online Access:http://hdl.handle.net/10261/205613
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/100012818
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spelling dig-cial-es-10261-2056132021-12-27T16:51:45Z Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer Cueva, Carolina Silva, Mariana Pinillos, Iris Bartolomé, Begoña Moreno-Arribas, M. Victoria Ministerio de Economía y Competitividad (España) Comunidad de Madrid Colorectal cancer Oral microbiota Gut microbiota Dysbiosis Diet Polyphenol metabolites This article belongs to the Special Issue Dietary Patterns, Dietary Indices for Colorectal Cancer, Mortality and the Related Disease. Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications. Research in our lab is funded by the Spanish Ministry of Science and Innovation (AGL2015-64522-C2-1 project), and the Comunidad de Madrid Program (ALIBIRD-CM 2020 P2018/BAA-4343). M.S is the recipient of a postdoctoral contract from CM-Garantía Juvenil Programme. Peer reviewed 2020-03-27T13:25:52Z 2020-03-27T13:25:52Z 2020 2020-03-27T13:25:52Z artículo http://purl.org/coar/resource_type/c_6501 Nutrients 12(3): 625 (2020) http://hdl.handle.net/10261/205613 10.3390/nu12030625 2072-6643 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100012818 32120799 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64522-C2-1-R S2018/BAA-4343/ALIBIRD2020-CM Publisher’s version https://doi.org/10.3390/nu12030625 artículo open Multidisciplinary Digital Publishing Institute
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
topic Colorectal cancer
Oral microbiota
Gut microbiota
Dysbiosis
Diet
Polyphenol metabolites
Colorectal cancer
Oral microbiota
Gut microbiota
Dysbiosis
Diet
Polyphenol metabolites
spellingShingle Colorectal cancer
Oral microbiota
Gut microbiota
Dysbiosis
Diet
Polyphenol metabolites
Colorectal cancer
Oral microbiota
Gut microbiota
Dysbiosis
Diet
Polyphenol metabolites
Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
description This article belongs to the Special Issue Dietary Patterns, Dietary Indices for Colorectal Cancer, Mortality and the Related Disease.
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
format artículo
topic_facet Colorectal cancer
Oral microbiota
Gut microbiota
Dysbiosis
Diet
Polyphenol metabolites
author Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
author_sort Cueva, Carolina
title Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
title_short Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
title_full Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
title_fullStr Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
title_full_unstemmed Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
title_sort interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://hdl.handle.net/10261/205613
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/100012818
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