Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress.

Bibliographic Details

Main Authors:	Garcés Rimón, M., González, Cristina, Hernanz, Raquel, Herradón, Esperanza, Martín, Ángela, Palacios, Roberto, Alonso, M. J., Uranga-Ocio, José Antonio, López-Miranda, Visitación, Miguel, Marta
Other Authors:	Ministerio de Ciencia, Innovación y Universidades (España)
Format:	artículo biblioteca
Language:	English
Published:	Wiley-VCH 2019
Subjects:	Cardiovascular diseases, Egg white proteins, Enzymatic hydrolysis, Metabolic syndrome, Zucker rats,
Online Access:	http://hdl.handle.net/10261/204788 http://dx.doi.org/10.13039/501100003329
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