Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells

Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells

Resumen del trabajo presentado al American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting, celebrado en San Francisco, California (USA) del 22 al 25 de febrero de 2019.

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Main Authors: López-Fandiño, Rosina, Lozano-Ojalvo, Daniel, Martínez-Blanco, Mónica, Pérez-Rodríguez, Leticia, Molina, Elena, Peláez, Carmen, Requena, Teresa
Format: póster de congreso biblioteca
Language:English
Published: 2019
Online Access:http://hdl.handle.net/10261/195485
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spelling dig-cial-es-10261-1954852019-11-26T01:57:12Z Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells López-Fandiño, Rosina Lozano-Ojalvo, Daniel Martínez-Blanco, Mónica Pérez-Rodríguez, Leticia Molina, Elena Peláez, Carmen Requena, Teresa Resumen del trabajo presentado al American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting, celebrado en San Francisco, California (USA) del 22 al 25 de febrero de 2019. [Rationale] Oral immunotherapy (OIT) with peptides has proved more effective than that with intact allergens in providing desensitization against food allergy. The mechanism by which food peptides confer higher protection was investigated. [Methods] BALB/c mice sensitized to egg white (EW) with the aid of cholera toxin (CT) were subjected to OIT with intact and pepsin-hydrolysed EW (EP). Changes in the caecal microbiota and its metabolism, generation of barrier-protective responses in the small and large intestine and expansion of regulatory T cells were studied. [Results] Treatment with EP was superior to that with EW in terms of reduction of anaphylaxis and levels of specific antibodies. OIT with EP, but not with EW, modulated the microbiota by restoring the levels of some members of the order Clostridiales (clusters IV and XIVa) that were affected by CT-induced sensitization. Mice treated with EP exhibited upregulated intestinal expression of Il22 and Muc2, which encode for factors that contribute to reinforce the epithelial barrier function, as well as Aldh1a1, Aldh1a2 and Tfgb1, that take part in the conversion of vitamin A into retinoic acid. Tolerance induced by EP paralleled the enhanced expression of Foxp3, Rorc and Il17 in non-lymphoid and lymphoid tissues and the development of Foxp3+ cells that simultaneously expressed RORγt. [Conclusions] The benefits of peptide OITwere associated to vitamin A metabolism and development of immune cells that depend on RORγt for their transcriptional regulation. Peer reviewed 2019-11-25T12:31:48Z 2019-11-25T12:31:48Z 2019 póster de congreso http://purl.org/coar/resource_type/c_6670 American Academy of Allergy, Asthma and Immunology Annual Meeting (2019) http://hdl.handle.net/10261/195485 en Sí none
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
description Resumen del trabajo presentado al American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting, celebrado en San Francisco, California (USA) del 22 al 25 de febrero de 2019.
format póster de congreso
author López-Fandiño, Rosina
Lozano-Ojalvo, Daniel
Martínez-Blanco, Mónica
Pérez-Rodríguez, Leticia
Molina, Elena
Peláez, Carmen
Requena, Teresa
spellingShingle López-Fandiño, Rosina
Lozano-Ojalvo, Daniel
Martínez-Blanco, Mónica
Pérez-Rodríguez, Leticia
Molina, Elena
Peláez, Carmen
Requena, Teresa
Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
author_facet López-Fandiño, Rosina
Lozano-Ojalvo, Daniel
Martínez-Blanco, Mónica
Pérez-Rodríguez, Leticia
Molina, Elena
Peláez, Carmen
Requena, Teresa
author_sort López-Fandiño, Rosina
title Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
title_short Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
title_full Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
title_fullStr Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
title_full_unstemmed Peptide-based immunotherapy enhances vitamin A metabolism and induces RORγt+ regulatory T cells
title_sort peptide-based immunotherapy enhances vitamin a metabolism and induces rorγt+ regulatory t cells
publishDate 2019
url http://hdl.handle.net/10261/195485
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