Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins
[Background] The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP).
| Main Authors: | , , , |
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| Format: | artículo biblioteca |
| Published: |
BioMed Central
2017-05-12
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| Subjects: | Adverse outcome pathway, Key events, Key event relations, Food allergy, Sensitization, Mechanistic understanding, Food proteins, Molecular initiating event, |
| Online Access: | http://hdl.handle.net/10261/149725 |
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