Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Show other versions (1)

Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

Saved in:
Bibliographic Details
Main Authors: Pain, A., Renauld, H., Berriman, M., Murphy, L., Yeats, C.A., Weir, W., Kerhornou, A., Aslett, M., Bishop, Richard P., Bouchier, C., Cochet, M., Coulson, R.M.R., Cronin, A., Villiers, Etienne P. de, Fraser, A., Fosker, N., Gardner, M., Goble, A., Griffiths-Jones, S., Harris, D.E., Katzer, F., Larke, N., Lord, A., Maser, P., McKellar, S., Mooney, P., Morton, F., Nene, Vishvanath, O'Neil, S., Price, C., Quail, M.A., Rabbinowitsch, E., Rawlings, N.D., Rutter, S., Saunders, D., Seeger, K., Shah, Tushaar, Squares, R., Squares, S., Tivey, A., Walker, A.R., Woodward, J., Dobbelaere, D.A.E., Langsley, G., Rajandream, M.A., McKeever, Declan J., Shiels, B., Tait, A., Barrell, B., Hall, N.
Format: Journal Article biblioteca
Language:English
Published: American Association for the Advancement of Science 2005-07
Subjects:parasites, theileria annulata, theileria parva,
Online Access:https://hdl.handle.net/10568/21171
https://doi.org/10.1126/science.1110418
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://hdl.handle.net/10568/21171
https://doi.org/10.1126/science.1110418

Similar Items