SARS-CoV-2 in eight municipalities of the Colombian tropics: high immunity, clinical and sociodemographic outcomes

Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Eight municipalities with the largest populations were chosen and 2564 blood samples were taken. A commercial enzyme-linked immunosorbent assay was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data, which were analysed by statistical methods.A seroprevalence of 40.8% was obtained for SARS-CoV-2 in the Córdoba region. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 for gender or age range (p>0.05). Higher seropositivity was found in low socio-economic status and symptomatic patients (p<0.0001). A total of 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which could be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (p<0.05).The high seropositivity in Córdoba is due to widespread SARS-CoV-2 in this population. The relationship between seropositivity and socio-economic status suggests a higher exposure risk to the virus caused by informal economic activities in low-income groups. Clinical manifestations such as anosmia and ageusia could be clinical predictors of infection by the new emergent coronavirus.

Bibliographic Details

Main Authors:	Garay, Evelin, Serrano Coll, Hector, Rivero, Ricardo, Gastelbondo, Bertha, Faccini Martinez, Alvaro, Berrocal, Jose, Perez, Alejandra, Badillo, Maria, Martinez Bravo, Caty, Botero, Yesica, Arrieta, German, Calderon, Alfonso, Galeano, Ketty, Lopez, Yesica, Miranda, Jorge, Guzman, Camilo, Contreras, Veronica, Arosemena, Alejandra, Contreras, Hector, Brango Tarra, Eimi, Oviedo Pastrana, Misael Enrique, Mattar, Salim
Format:	article biblioteca
Language:	eng
Published:	Oxford University Press 2021
Subjects:	Investigación agropecuaria - A50, Zona tropical, Demografía, Coronavirus del síndrome respiratorio agudo grave 2, Salud pública, Transversal, http://aims.fao.org/aos/agrovoc/c_7979, http://aims.fao.org/aos/agrovoc/c_10328, http://aims.fao.org/aos/agrovoc/c_365a18ab, http://aims.fao.org/aos/agrovoc/c_6349,
Online Access:	https://doi.org/10.1093/trstmh/trab094 http://hdl.handle.net/20.500.12324/38929
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