A compact miniaturized flow system based on low-temperature co-fired ceramic technology coupled to led mini-photometer for determination of dipyrone in pharmaceutical formulations.

In this work, an analytical microsystem based on LTCC (low-temperature co-fired ceramic) technology with monolithic incorporation of an optical flow cell for determination of dipyrone in pharmaceuticals is described. The detection system is based on the formation of a blue chromophore between dipyrone and Fe(III) photometrically monitored at 630 nm using a lab-made LED mini-photometer constructed with a light emitting diode as a radiation source and a Si photodiode as a detector. The lab-made mini-photometer elaborated presented a good performance in regard to high signal/noise ratio, low drift and good sensitivity. The analytical curve was linear in the dipyrone concentration range from 1.0 × 10-4 to 3.5 × 10-3 mol L-1, limit of detection of 4.5 × 10-5 mol L-1 and total time of analyses of 20 s yielding an analytical frequency of 195 h-1 with a low waste generation per analysis (480 µL).

Bibliographic Details

Main Authors:	SUAREZ, W. T., PESSOA NETO, O. D., SANTOS, V. B. dos, NOGUEIRA, A. R. de A., FARIA, R. C., FATIBELLO-FILHO, O., CHAMARRO, J. A.
Other Authors:	WILLIAN T. SUAREZ, Universidade Federal de Viçosa; OSMUNDO D. PESSOA-NETO, Universidade Federal de São Carlos; VAGNER B. DOS SANTOS, Universidade Federal de São Carlos; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; RONALDO C. FARIA, Universidade Federal de São Carlos; ORLANDO FATIBELLO-FILHO, Universidade Federal de São Carlos; JULIÁN A. CHAMARRO, Universitat Autònoma de Barcelona.
Format:	Artigo de periódico biblioteca
Language:	Ingles English
Published:	2013-06-04
Subjects:	Low temperature, Co-fired ceramic, Analytical microsystems, Dipyrone, Flow injection, LED photometer,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/959237 https://doi.org/10.5935/0103-5053.20130112
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